Positive and negative regulatory elements contribute to CpG oligonucleotide-mediated regulation of human IL-6 gene expression
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چکیده
منابع مشابه
Positive and Negative Regulation O’e Il-2 Gene Expression: Role Of’ Multn I% Regulatory Sites
Interleukin 2 (IL-2) is an important lymphokine required in the process of T cell activation, proliferation, clonal expansion and differentiation. The IL-2 gene displays both T cell specilic ahd inducible expression: it is only expressed in CD4+ T cells after antigenic or mitogenic stimulation. Several cis-acting regulatory sites are required for induction of the IL-2 gene after stimulation. In...
متن کاملPositive and negative regulatory elements in the mouse albumin enhancer.
Most enhancer elements so far described are comprised of multiple DNA binding sites for proteins that act to increase the rate of transcription. In this report we show that the far upstream mouse albumin enhancer element (-10.5 to -8.5 kilobase pairs) is a composite of at least three functional regions: a negative region that suppresses an otherwise positive, liver-specific enhancer element and...
متن کاملIdentification of positive and negative transcriptional regulatory elements of the rabbit angiotensin-converting enzyme gene.
The two tissue-specific mRNAs encoding the isozymes of rabbit angiotensin-converting enzyme (ACE) are generated from the same gene by alternative choice of two transcription initiation sites 5.7 kb apart. In the current study, we have characterized the regulatory sites controlling the transcription of the larger pulmonary isozyme mRNA. For this purpose, reporter genes driven by varying lengths ...
متن کاملDiscrete positive and negative thyroid hormone-responsive transcription regulatory elements of the rat growth hormone gene.
We have recently shown that a thyroid hormone-responsive transcription stimulatory element exists in the 5'-flanking DNA near the rat growth hormone (rGH) gene (Crew, M. D., and Spindler, S. R. (1986) J. Biol. Chem. 261, 5018-5022). Progressive deletion-transfection analysis of the 5' end of the gene has led to the identification of two genetic elements responsive to thyroid hormone. The first ...
متن کاملExpression of angiopoietin-2 in endothelial cells is controlled by positive and negative regulatory promoter elements.
OBJECTIVE Angiopoietin-2 (Ang-2) is a non-signal transducing ligand of the endothelial receptor tyrosine kinase Tie-2. Ang-2 is produced by endothelial cells and acts as an autocrine regulator mediating vascular destabilization by inhibiting Angiopoietin-1-mediated Tie-2 activation. To examine the transcriptional regulation of Ang-2, we studied the Ang-2 promoter in endothelial cells and nonend...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2000
ISSN: 0014-2980,1521-4141
DOI: 10.1002/1521-4141(200001)30:1<108::aid-immu108>3.3.co;2-w